Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

3 papers

Sex differences in anxiety and depression: Role of testosterone

Jenna A. McHenry, Nicole Carrier, Elaine M. Hull, Mohamed Kabbaj
Frontiers in Neuroendocrinology Summary & key facts 2013 487 citations

This review examines studies on how testosterone relates to anxiety and depression and how that might help explain sex differences in these disorders. About 18% of U.S. adults have an anxiety disorder each year and about 7% have major depressive disorder, and women are more than twice as likely as…

Hormonal and reproductive studies Neuroendocrine regulation and behavior Stress Responses and Cortisol

Alcohol, stress hormones, and the prefrontal cortex: A proposed pathway to the dark side of addiction

Yi-Ling Lu, Heather N. Richardson
Neuroscience Summary & key facts 2014 78 citations

This review paper brings together animal and human studies to explain how alcohol and stress hormones may change the prefrontal cortex and the body’s stress system as drinking moves from casual use toward dependence. The authors say alcohol raises stress hormones (glucocorticoids) right away, and repeated heavy use can produce…

Neuroendocrine regulation and behavior Stress Responses and Cortisol Tryptophan and brain disorders

Peripubertal stress increases play fighting at adolescence and modulates nucleus accumbens CB1 receptor expression and mitochondrial function in the amygdala

Aurélie Papilloud, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Jocelyn Grosse, Carmen Sandi
Translational Psychiatry Summary & key facts 2018 40 citations

This rat study tested whether stress during the peripuberty period (seven non-consecutive days between postnatal day 28 and 42) changed play fighting at adolescence and later brain markers. Rats exposed to peripubertal stress showed more play fighting at P45. The researchers found that animals with very high play fighting in…

Neuroendocrine regulation and behavior Stress Responses and Cortisol Tryptophan and brain disorders
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