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Frontier mental health research: psychedelics & drug studies

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Biochemistry, Genetics and Molecular Biology Journal of Medicinal Chemistry

1 paper

What We Have Gained from Ibogaine: α3β4 Nicotinic Acetylcholine Receptor Inhibitors as Treatments for Substance Use Disorders

Carolyn J. Straub, Lisa E. Rusali, Kyle M. Kremiller, Andrew P. Riley
Journal of Medicinal Chemistry Summary & key facts 2022 16 citations

Researchers reviewing ibogaine and its chemical relatives say these drugs point to a new way to treat substance use disorders by blocking a brain receptor called α3β4 nicotinic acetylcholine receptor (nAChR). Animal studies found ibogaine and some derivatives reduced self-use of drugs like morphine, cocaine, alcohol, and nicotine. But ibogaine…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Nicotinic Acetylcholine Receptors Study
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.