Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

10 papers

Polyvagal Theory: A Science of Safety

Stephen W. Porges

This 2022 paper by Stephen Porges presents Polyvagal Theory as a way to study how feelings of safety come from the body's nervous system. It proposes that safety is not just a mood but has measurable brain–body signals. The paper explains neural pathways (like the ventral vagal complex and a…

Heart Rate Variability and Autonomic Control Neural and Behavioral Psychology Studies Psychosomatic Disorders and Their Treatments

Fatigue and Human Performance: An Updated Framework

Martin Behrens, Martin Gube, Hélmi Chaabène, Olaf Prieske, Alexandre Zénon, Kim‐Charline Broscheid, et al.
Sports Medicine Summary & key facts 2022 249 citations

This narrative review updates an earlier fatigue framework and proposes a clearer way to think about fatigue during tasks. It defines motor or cognitive task-induced state fatigue as a psychophysiological condition that can show up as a drop in performance and/or a stronger feeling of tiredness. The authors add cognitive…

Heart Rate Variability and Autonomic Control Occupational Health and Performance Sleep and Work-Related Fatigue

Effects of voluntary slow breathing on heart rate and heart rate variability: A systematic review and a meta-analysis

Sylvain Laborde, Mark S. Allen, Uirassu Borges, Fabrice Dosseville, Thomas J. Hosang, Maša Iskra, et al.
PubMed Summary & key facts 2022 205 citations

This 2022 systematic review and meta-analysis pooled data from 223 studies to see if voluntary slow breathing (VSB) changes heart rate variability that reflects parasympathetic (vagal) control of the heart. The authors found that VSB increased vagally-mediated heart rate variability during breathing sessions, right after a single session, and after…

Cardiac Health and Mental Health Cardiovascular and exercise physiology Heart Rate Variability and Autonomic Control

Moderate Pressure Massage Elicits a Parasympathetic Nervous System Response

Miguel Diego, Tiffany Field

In a randomized trial of 20 healthy adults, researchers recorded EKGs during a 3-minute baseline, a 15-minute massage, and a 3-minute postmassage period. Moderate pressure massage raised the high-frequency (HF) heart-rate variability measure and lowered the LF/HF ratio, which the authors say indicates increased parasympathetic (vagal) activity peaking in the…

Acupuncture Treatment Research Studies Heart Rate Variability and Autonomic Control Psychosomatic Disorders and Their Treatments

Effect of breathwork on stress and mental health: A meta-analysis of randomised-controlled trials

Guy W. Fincham, Clara Strauss, Jesús Montero‐Marín, Kate Cavanagh
Scientific Reports Summary & key facts 2023 158 citations

This meta-analysis looked at randomized trials to see if deliberate breathing practices (breathwork) reduce self-reported stress. Across 12 trials with 785 adults, breathwork was linked with a small-to-medium drop in stress compared with non-breathwork controls (g = -0.35). Similar small-to-medium effects were seen for anxiety and depression. Most included studies…

Health and Wellbeing Research Health, psychology, and well-being Heart Rate Variability and Autonomic Control

Benefits from one session of deep and slow breathing on vagal tone and anxiety in young and older adults

Valentin Magnon, Fréderic Dutheil, Guillaume T. Vallet
PubMed Summary & key facts 2021 124 citations

This clinical trial tested one session of deep and slow breathing (DSB) in 47 adults (22 older, 25 younger). After the single DSB session, high-frequency (HF) heart rate variability increased and self-reported state anxiety went down in both age groups. The rise in HF power was significantly larger in older…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Behavioral Health and Interventions Heart Rate Variability and Autonomic Control

Effect of long-term yoga training on autonomic function among the healthy adults

R Shobana, Maheshkumar Kuppusamy, Sankaralingam Thirupathy Venkateswaran, M Bagavad Geetha, R. Padmavathi

This small cross-sectional study compared 33 regular yoga practitioners with 35 non‑practitioners aged 17–30. The yoga group had a lower resting heart rate (about 69 vs 81 bpm) and a smaller blood‑pressure response on the sustained handgrip test (about 10.2 vs 16.3), differences the authors report as statistically significant. Other…

Heart Rate Variability and Autonomic Control Mindfulness and Compassion Interventions Stress Responses and Cortisol

Revealing the Complexity of Fatigue: A Review of the Persistent Challenges and Promises of Artificial Intelligence

Thorsten Rudroff
Brain Sciences Summary & key facts 2024 17 citations

This review explains why fatigue is hard to study and how artificial intelligence (AI) might help. Fatigue is a personal, subjective feeling that shows up in many ways and comes from many interacting body systems. That makes it hard to measure, compare across people, and link to clear biological causes.…

Fibromyalgia and Chronic Fatigue Syndrome Research Heart Rate Variability and Autonomic Control Occupational Health and Safety Research

Cardiac arrest after ibogaine intoxication

Christian Steinberg, Marc W. Deyell
Journal of Arrhythmia Summary & key facts 2018 15 citations

Ibogaine is a psychoactive herbal medication with alleged antiaddiction properties. We report a case of ibogaine intoxication mimicking Long-QT syndrome resulting in ventricular flutter and nearby cardiac arrest. A 61-year-old man experienced massive QT prolongation and ventricular flutter at a rate of 270 beats per minute requiring defibrillation after ingestion…

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Neurotransmitter Receptor Influence on Behavior

Mental health disorders and their impact on cardiovascular health disparities

Viola Vaccarino, Eva Prescott, Amit J Shah, J Douglas Bremner, Paolo Raggi, Olivija Dobiliene, et al.
PubMed Central (PMC) Summary & key facts 2025 7 citations

This review found that mental health disorders are common and closely linked with worse heart health. People with conditions like depression, anxiety, schizophrenia, bipolar disorder, or PTSD have higher rates of cardiovascular disease and higher death rates from it. The reasons include biology, behaviours, and problems in health care. The…

Cardiac Health and Mental Health Health, psychology, and well-being Mental Health Treatment and Access
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