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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Psychedelics and Drug Studies Cellular and Molecular Neuroscience

2 papers

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

Marton, Soledad, González, Bruno, Rodríguez-Bottero, Sebastián, et al.
www.frontiersin.org Summary & key facts 2019 65 citations

In this rat study, animals got a single injection of ibogaine at 20 mg/kg or 40 mg/kg and the researchers measured three neurotrophic factors (GDNF, BDNF, NGF) in four brain regions (VTA, prefrontal cortex, nucleus accumbens, substantia nigra) at 3 and 24 hours. The main changes appeared at 24 hours:…

Nerve injury and regeneration Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

The pharmacokinetics and pharmacodynamics of ibogaine in opioid use disorder patients

Thomas Knuijver, Rob ter Heine, Arnt Schellekens, Paniz Heydari, Luc Lucas, Sjoerd Westra, et al.
Journal of Psychopharmacology Summary & key facts 2024 8 citations

In 14 people with opioid use disorder who each received a single 10 mg/kg dose of ibogaine, researchers measured blood levels of ibogaine and its metabolites over 24 hours and linked those levels to side effects. They found large differences between people in how fast ibogaine was cleared, and that…

Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Treatment of Major Depression
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.