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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Tryptophan and brain disorders Cellular and Molecular Neuroscience

1 paper

Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors

Vesna Lazarevic, Yunting Yang, Ivana Flais, Per Svenningsson
Molecular Psychiatry Summary & key facts 2021 71 citations

This study in rodents and in neuronal cell cultures found that ketamine and its antidepressant metabolite (2R,6R)-HNK rapidly lower neuronally released glutamate in brain regions linked to depression. Using fast glutamate sensors (FAST), isolated synapses, and primary cortical neurons, the authors showed reduced depolarization-evoked glutamate release within 30 minutes after…

Neuroscience and Neuropharmacology Research Treatment of Major Depression Tryptophan and brain disorders
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