Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
The researchers created personalized brain circuit scores from both task-free and task-evoked fMRI scans in a large group of people with depression and anxiety. Using a standardized processing method, they measured 41 circuit features across six brain systems and used those measures to define six distinct “biotypes.” These biotypes showed…
This article explains that a brain network called the default mode network (DMN) supports self-related thoughts and autobiographical memory and helps form a stable sense of self. In people with PTSD, the DMN shows substantially reduced connectivity at rest compared with healthy people, and bigger reductions are linked with worse…
This paper is a systematic review and meta-analysis of resting-state fMRI studies that compared people with diagnosed anxiety disorders to healthy controls. The authors searched 1,226 records and then ran a coordinate-based meta-analysis (ALE) only on seed-based rs-fMRI studies because other study types were too few. The meta-analysis found reduced…
Ketamine is a drug that blocks NMDA glutamate receptors and can produce symptoms like those of schizophrenia in healthy people. In this multicenter study the researchers compared resting-state brain scans after ketamine or placebo and looked at key brain networks, the dorsolateral prefrontal cortex (DLPFC), and thalamic sub-nuclei. They found…
