Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

4 papers

Fear and the Defense Cascade

Kasia Kozlowska, Peter G. Walker, Loyola McLean, Pascal Carrive
Harvard Review of Psychiatry Summary & key facts 2015 429 citations

Evolution has endowed all humans with a continuum of innate, hard-wired, automatically activated defense behaviors, termed the defense cascade. Arousal is the first step in activating the defense cascade; flight or fight is an active defense response for dealing with threat; freezing is a flight-or-fight response put on hold; tonic…

Memory and Neural Mechanisms Neuroendocrine regulation and behavior Stress Responses and Cortisol

The social brain and reward: social information processing in the human striatum

Jamil P. Bhanji, Mauricio R. Delgado

This 2014 review explains that the brain’s reward system — especially a region called the striatum — responds not only to things like food or money but also to social outcomes such as praise. The authors summarize many studies showing that the striatum carries signals when people evaluate social rewards,…

Neural and Behavioral Psychology Studies Neuroendocrine regulation and behavior Neurotransmitter Receptor Influence on Behavior

Socially-induced brain ‘fertilization’: play promotes brain derived neurotrophic factor transcription in the amygdala and dorsolateral frontal cortex in juvenile rats

Nakia S. Gordon, Sharon Burke, Huda Akil, Stanley J. Watson, Jaak Panksepp
Neuroscience Letters Summary & key facts 2003 108 citations

Researchers studied 32-day-old juvenile rats that were allowed 30 minutes of rough-and-tumble play. Right after play, the rats showed higher levels of BDNF messenger RNA in the amygdala and dorsolateral frontal cortex, measured with in situ hybridization. The authors suggested this could mean play helps shape brain areas tied to…

Autism Spectrum Disorder Research Child Development and Digital Technology Neuroendocrine regulation and behavior

A new understanding of the cognitive reappraisal technique: an extension based on the schema theory

Wang, Ya-Xin, Yin, Bin
www.frontiersin.org Summary & key facts 2023 44 citations

This 2023 hypothesis paper says cognitive reappraisal — changing how we interpret events to change our feelings — often works in labs or therapy but may not carry over to real life. The authors explain this by comparing reappraisal to extinction learning, which creates new, context-dependent memories instead of erasing…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Memory and Neural Mechanisms Neuroendocrine regulation and behavior
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