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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Health Sciences Chronic Pain Bioinformatics

1 paper

Esketamine has promising anti-inflammatory effects in orthopedic surgery and plays a protective role in postoperative cognitive function and pain management

Lichun Han
American Journal of Translational Research Summary & key facts 2025 10 citations

Researchers gave a low dose of esketamine through an IV before general anesthesia to 200 adults having planned orthopedic surgery. They compared 100 people who got esketamine with 100 who got a saline placebo. The esketamine group showed smaller rises in inflammatory proteins after surgery, higher levels of antibodies, less…

Anesthesia and Neurotoxicity Research Anesthesia and Sedative Agents Treatment of Major Depression Ketamine
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