Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

8 papers

The Health-Related Quality of Life for Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)

Michael Falk Hvidberg, Louise Brinth, Anne Vingaard Olesen, Karin Dam Petersen, Lars Holger Ehlers
PLoS ONE Summary & key facts 2015 212 citations

This study measured health-related quality of life (HRQoL) in Danish patients with ME/CFS using the EQ-5D-3L tool and found their scores were much lower than the general population and lower than 20 other conditions. The average (unadjusted) EQ-5D-3L score for the ME/CFS group was 0.47, while the population average was…

Fibromyalgia and Chronic Fatigue Syndrome Research Resilience and Mental Health

Evaluation of a Single Dose of Ferric Carboxymaltose in Fatigued, Iron-Deficient Women – PREFER a Randomized, Placebo-Controlled Study

Bernard Favrat, Katharina Balck, Christian Breymann, Michael Hedenus, Thomas Keller, Anna Mezzacasa, et al.
PLoS ONE Summary & key facts 2014 129 citations

This was a single-blinded, randomized trial of 290 premenopausal women with unexplained fatigue and low iron who received one 1000 mg IV dose of ferric carboxymaltose (FCM) or saline placebo. By Day 56, more women given FCM had reduced fatigue and larger improvements in some quality-of-life and cognitive scores, and…

Erythropoietin and Anemia Treatment Iron Metabolism and Disorders Pharmacological Effects and Toxicity Studies

Experiences of criticism in adults with ADHD: A qualitative study

Danielle M. Beaton, Fuschia M. Sirois, Elizabeth Milne
PLoS ONE Summary & key facts 2022 46 citations

Attention‑deficit/hyperactivity disorder (ADHD) is a common, long‑term condition that begins in childhood. The main symptoms are trouble paying attention, having too much activity, and acting without thinking. These symptoms can cause problems at home, at school or work, and in relationships. About 8.4% of children and 2.5% of adults are…

Attention Deficit Hyperactivity Disorder Behavioral and Psychological Studies Neural and Behavioral Psychology Studies

A double-edged hashtag: Evaluation of #ADHD-related TikTok content and its associations with perceptions of ADHD

Vasileia Karasavva, C. Miller, Nicole B. Groves, Andrés Montiel, Will H. Canu, Amori Yee Mikami
PLoS ONE Summary & key facts 2025 25 citations

Researchers analyzed the top 100 TikTok videos tagged #ADHD and asked 843 college students about their TikTok use and views of those videos. Two clinical psychologists rated the top 100 videos and found that fewer than half of the claims about ADHD symptoms matched the Diagnostic and Statistical Manual of…

Attention Deficit Hyperactivity Disorder Digital Mental Health Interventions Impact of Technology on Adolescents

Interoceptive awareness in attention deficit hyperactivity disorder

Jan R. Wiersema, Elke Godefroid
PLoS ONE Summary & key facts 2018 20 citations

This 2018 study asked whether adults with ADHD can notice their bodily signals (interoceptive awareness). The researchers compared 24 adults with ADHD to 23 adults without ADHD. They used a heartbeat perception task (an objective test) and a questionnaire (a subjective test). Both groups performed similarly on both measures. The…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Attention Deficit Hyperactivity Disorder Psychosomatic Disorders and Their Treatments

Real-world clinical predictors of manic/hypomanic episodes among outpatients with bipolar disorder

Keita Tokumitsu, Yasui-Furukori Norio, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, et al.
journals.plos.org Summary & key facts 2021 12 citations

This Japanese study looked at 2,231 outpatients with bipolar disorder and found that 29.1% had a manic or hypomanic episode within one year. Lower functioning (lower GAF score), rapid cycling, a coexisting personality disorder, bipolar I diagnosis, substance abuse, and being in a manic or mixed mood at the start…

Bipolar Disorder and Treatment Electroconvulsive Therapy Studies Schizophrenia research and treatment

Natural soundscapes enhance mood recovery amid anthropogenic noise pollution

Lia R. V. Gilmour, Isabelle Bray, Chris Alford, Paul R. Lintott
PLoS ONE Summary & key facts 2024 6 citations

Researchers played three 3‑minute sound recordings to 68 university students: a natural dawn chorus of birds, that same recording with added traffic noise recorded at a 20 mi/h road, and the recording with traffic from a 40 mi/h road. Participants reported the lowest anxiety and stress and the most positive…

Multisensory perception and integration Noise Effects and Management Urban Green Space and Health

Improvements in health-related quality of life are maintained long-term in patients prescribed medicinal cannabis in Australia: The QUEST Initiative 12-month follow-up observational study

Margaret-Ann Tait, Daniel Costa, Rachel Campbell, Leon N. Warne, Richard Norman, Stephan A. Schug, et al.
PLoS ONE Summary & key facts 2025 3 citations

This large Australian real-world study followed 2,353 adults who were newly prescribed medicinal cannabis oil and found that patient-reported quality of life, fatigue, sleep, pain (in people with chronic pain), and mood (in people with anxiety or depression) showed statistically significant and clinically meaningful improvements that were maintained up to…

Bipolar Disorder and Treatment Cannabis and Cannabinoid Research Sleep and related disorders
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