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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Health Sciences Cannabis Chemistry

1 paper

Δ9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus

Nora Laaris, Cameron H. Good, Carl R. Lupica
Neuropharmacology Summary & key facts 2010 82 citations

In mouse hippocampal brain slices, the researchers found that Δ9‑tetrahydrocannabinol (Δ9‑THC) strongly activates CB1 cannabinoid receptors on GABA‑releasing axon terminals and reduces GABA release. The effect depended on how Δ9‑THC was dissolved, required CB1 receptors, and did not come from changing GABA receptors or GABA uptake. The results point to…

Cannabis and Cannabinoid Research Neuroscience and Neuropharmacology Research Sleep and Wakefulness Research Cannabis
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