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38 papers
Some research suggests that whole-plant cannabis compounds (like THC, CBD, other cannabinoids, terpenes, and flavonoids) can interact so the plant’s effects differ from CBD alone. Healthline explains three CBD types — full-spectrum, broad-spectrum, and isolate — and notes legal, safety, and labeling limits. The article says there is evidence for…
The endocannabinoid system (ECS) is a widespread brain signaling system made of cannabinoid receptors, naturally made lipid messengers, and the enzymes that make and break those messengers. The two best-studied messengers are 2-AG and anandamide, and they are produced and degraded by different enzyme pathways. CB1 receptors are common in…
This review says cannabidiol (CBD) is a non‑psychoactive cannabis compound that has antioxidant and anti‑inflammatory actions in lab and some clinical studies. CBD can act directly to neutralize reactive molecules and indirectly by changing cell signals and antioxidant enzymes. Experiments in cells and animals show CBD lowers markers of oxidative…
Folic acid is a stable, synthetic form of the vitamin folate. Taking folic acid around the time of conception lowers the chance of neural tube birth defects (NTDs). Many countries have added folic acid to flour and other foods. These fortification programs have been linked with large drops in NTDs,…
This review describes the endocannabinoid system (ECS) as a widespread network of natural cannabinoids, cannabinoid receptors (mainly CB1 and CB2), and the enzymes that make and break those chemicals. The ECS helps shape brain development and adjusts how neurons communicate. The authors note that THC is the main psychoactive part…
This review describes compounds in medicinal mushrooms and how they work in lab and animal studies. It lists many possible effects, such as immune changes, anti-inflammatory and anticancer actions, and names key molecules like polysaccharides (β-glucans), terpenes, and fungal proteins. Most evidence so far comes from in vitro or animal…
Hepcidin is a small hormone made in the liver that helps control how the body absorbs and moves iron. It lowers iron flow into the blood by blocking ferroportin, the only known iron exporter on intestinal cells, macrophages (immune cells), and liver cells. Hepcidin levels rise when iron is high…
This paper is a 2015 review that brings together many studies about the lion’s mane mushroom (Hericium erinaceus). It describes the mushroom’s chemical makeup, nutrients, food uses, and about 70 identified bioactive compounds. The review reports many claimed health effects seen in cell, animal, and some human studies—such as anti-inflammatory…
This laboratory study found that cannabidiol (CBD), a non‑psychoactive compound from Cannabis sativa, reduced fat production and inflammation in human sebaceous (oil) gland cells. The effects were seen in cultured human sebocytes and in human skin organ cultures, where CBD blocked the fat‑making (lipogenic) actions of several compounds. These results…
The study heated Cannabis sativa extracts at 80, 95, 110, 130, and 145 °C for up to 60 minutes and measured acidic and neutral cannabinoids with an advanced UHPSFC/PDA‑MS lab method. Concentrations changed in an exponential way, which fits a first‑order (or pseudo‑first‑order) reaction model. The team calculated rate constants…
This is a short 1970 Nature paper by E. W. Gill, W. D. Paton and R. G. Pertwee that reports preliminary experiments on the chemistry and pharmacology of cannabis. The PubMed entry has no abstract, but its indexing shows the paper looked at drug effects and toxicity, and at topics…
In rats and mice that had brain lesions used to model Parkinson's disease, the plant compound Δ9-THCV reduced movement problems after a single dose and, with repeated dosing, reduced loss of dopamine-producing neurons in the brain region called the substantia nigra. Some effects seem linked to antioxidant actions and, in…
