Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

3 papers

Cingulate dynamics track depression recovery with deep brain stimulation

Sankaraleengam Alagapan, Ki Sueng Choi, Stephen Heisig, Patricio Riva‐Posse, Andrea Crowell, Vineet Tiruvadi, et al.
Nature Summary & key facts 2023 233 citations

Researchers tested deep brain stimulation (DBS) in a small group of people whose depression did not get better with usual treatments. They used an implanted device that both delivered stimulation to the subcallosal cingulate (a brain area linked to mood) and recorded brain electrical signals. Around 9 out of 10…

Functional Brain Connectivity Studies Neurological disorders and treatments Transcranial Magnetic Stimulation Studies

Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study

Zack Shan, Richard Kwiatek, Richard Burnet, Peter Del Fante, Donald Staines, Sonya Marshall‐Gradisnik, et al.

The results suggested that CFS is associated with IFOF WM deficits which continue to deteriorate at an abnormal rate. J. Magn. Reson. Imaging 2016;44:1301-1311.

Fibromyalgia and Chronic Fatigue Syndrome Research Musculoskeletal pain and rehabilitation Psychosomatic Disorders and Their Treatments

Mania-related effects on structural brain changes in bipolar disorder – a narrative review of the evidence

Christoph Abé, Benny Liberg, Anna Luisa Klahn, Predrag Petrovic, Mikael Landén
PubMed Central (PMC) Summary & key facts 2023 39 citations

Long-term MRI studies show that people with bipolar disorder often have unusual brain changes over time, but the pattern is mixed and not fully clear. Some studies link manic episodes to faster thinning and volume loss in parts of the prefrontal cortex. A large multi-site study (307 patients, 925 controls,…

Bipolar Disorder and Treatment Functional Brain Connectivity Studies Schizophrenia research and treatment
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