Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

4 papers

Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study

Geoff Noller, Chris Frampton, Berra Yazar‐Klosinski

A single ibogaine treatment reduced opioid withdrawal symptoms and achieved opioid cessation or sustained reduced use in dependent individuals as measured over 12 months. Ibogaine's legal availability in New Zealand may offer improved outcomes where legislation supports treatment providers to work closely with other health professionals.

Opioid Use Disorder Treatment Prenatal Substance Exposure Effects Substance Abuse Treatment and Outcomes

Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes

Deborah C. Mash, Linda Duque, Bryan Page, Kathleen Allen-Ferdinand
Frontiers in Pharmacology Summary & key facts 2018 103 citations

Ibogaine is a psychoactive chemical from a West African shrub that some clinics use to help people stop using opioids or stimulants. Small studies, animal research, and many personal reports say a single high dose can cut opioid withdrawal and reduce cravings. For example, one study found 50% of participants…

Neurotransmitter Receptor Influence on Behavior Opioid Use Disorder Treatment Substance Abuse Treatment and Outcomes

Characteristics of and 3-month health outcomes for people seeking treatment with prescribed cannabis: Real-world evidence from Project Twenty21

Michael T. Lynskey, Anne Katrin Schlag, Alkyoni Athanasiou‐Fragkouli, David R. Badcock, David Nutt
Drug Science Policy and Law Summary & key facts 2023 19 citations

Project Twenty21 collected real-world data from people in the UK who sought prescribed medicinal cannabis. Data at treatment start were available for 2,833 patients and 1,410 had 3-month follow-up for anxiety, chronic pain or PTSD. On average, patients reported improvements in condition-specific symptoms and in general health and quality of…

Cannabis and Cannabinoid Research Homelessness and Social Issues Substance Abuse Treatment and Outcomes

Ketamine in Chronic Pain: A Review

Ana Faísco, Rita Lopes Dinis, T N Seixas, Luís Felipe Dias Lopes
Cureus Summary & key facts 2024 7 citations

This review says that low (sub-anesthetic) doses of ketamine can produce strong short-term pain relief by blocking NMDA receptors and by boosting descending pain-inhibiting pathways. It is well documented to help with pain around the time of surgery and is linked to less long-term postoperative pain and lower opioid use.…

Anesthesia and Pain Management Pain Mechanisms and Treatments Treatment of Major Depression
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.