Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
This review found that Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share many symptoms and similar biological changes. People with both conditions often have long-lasting fatigue, thinking problems, sleep disruption, pain, post-exertional worsening, and signs of problems in the brain, autonomic nervous system, heart, lungs, immune system, gut microbiome,…
This is the largest study characterising subjective brain fog as an impairment of concentration associated with functional impairments in activities of daily living. Brain fog was particularly associated with a history of long-COVID-19, migraines, concussion, and with 0.1 standard deviations lower cognitive scores, especially on modified Stroop testing, suggesting impairments…
This narrative review examines how panic disorder causes sudden, distressing body symptoms that can look like real medical problems. It focuses on six common symptoms (non-cardiac chest pain, palpitations, dyspnea, dizziness, abdominal distress, and paresthesia), reviews medical illnesses that can occur with or mimic panic (including long COVID), and argues…
This Nature news feature by Lynne Peeples (10 December 2025) looks at new research on mental fatigue — why thinking hard can make people feel worn out. It explains that scientists are trying to build better ways to measure cognitive exhaustion. The article says those better measures could help point…
This editorial pulls together recent research on fatigue. It notes that fatigue is common, can come from body or brain processes, and can be mild in healthy people or very disabling in illnesses like ME/CFS, long COVID, and MS. The authors report specific numbers from large reviews, describe studies on…
