Frontier mental health research: psychedelics & drug studies

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6 papers

Long-Term Occupational Stress Is Associated with Regional Reductions in Brain Tissue Volumes

Eva Blix, Aleksander Perski, Hans Berglund, Ivanka Savic
PLoS ONE Summary & key facts 2013 131 citations

Several brain-imaging studies found that people with long-term work-related burnout showed differences in brain structure and function compared with matched healthy adults. In groups where participants had worked more than about 60–70 hours per week for several years, researchers reported larger amygdala size, thinner medial prefrontal cortex (mPFC) tissue, weaker…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Functional Brain Connectivity Studies Stress Responses and Cortisol

Differential alterations of resting‐state functional connectivity in generalized anxiety disorder and panic disorder

HuiRu Cui, Jie Zhang, Yicen Liu, Qingwei Li, Hui Li, Lanlan Zhang, et al.
Human Brain Mapping Summary & key facts 2016 117 citations

Researchers compared whole-brain resting-state functional connectivity in 21 people with generalized anxiety disorder (GAD), 18 people with panic disorder (PD), and 22 matched healthy controls. They used a new measure called scaled correlation to look for differences across the brain. GAD showed stronger connections between the hippocampus/parahippocampus and the fusiform…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Functional Brain Connectivity Studies Neural dynamics and brain function

Safety of ibogaine administration in detoxification of opioid‐dependent individuals: a descriptive open‐label observational study

Thomas Knuijver, Arnt Schellekens, Maarten Belgers, Rogier Donders, Toon van Oosteren, Cornelis Kramers, et al.
Addiction Summary & key facts 2021 45 citations

A descriptive open-label observational study of ibogaine in people with opioid use disorder found the drug can produce clear but reversible heart and nervous-system side effects. Reported effects included QTc prolongation (a change in the heart’s electrical timing), slow heart rate (bradycardia), and severe problems with balance and coordination (ataxia).…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Neurotransmitter Receptor Influence on Behavior Substance Abuse Treatment and Outcomes

A new understanding of the cognitive reappraisal technique: an extension based on the schema theory

Wang, Ya-Xin, Yin, Bin
www.frontiersin.org Summary & key facts 2023 44 citations

This 2023 hypothesis paper says cognitive reappraisal — changing how we interpret events to change our feelings — often works in labs or therapy but may not carry over to real life. The authors explain this by comparing reappraisal to extinction learning, which creates new, context-dependent memories instead of erasing…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Memory and Neural Mechanisms Neuroendocrine regulation and behavior

Training Positive Rumination in Expressive Writing to Enhance Psychological Adjustment and Working Memory Updating for Maladaptive Ruminators

Hongfei Yang, Huizhong Li
Frontiers in Psychology Summary & key facts 2020 15 citations

This small experiment tested whether training people to use positive rumination during counselor-led expressive writing would help their mood and working memory. Nineteen undergraduates took part: 10 maladaptive ruminators had five weeks of the training and 9 were in a control group. After training, the trained group showed better psychological…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Mind wandering and attention Perfectionism, Procrastination, Anxiety Studies

Reward-related self-agency is disturbed in depression and anxiety

Marishka Mehta, Soojung Na, Xiaosi Gu, James W. Murrough, Laurel Morris
PLoS ONE Summary & key facts 2023 5 citations

Researchers tested a new task that measures how people feel they caused rewards or losses. They studied 52 healthy adults and 20 adults with depression or anxiety in person, and 254 people online. Healthy people felt more personal control after wins than after losses. People with depression or anxiety showed…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Neural and Behavioral Psychology Studies Psychosomatic Disorders and Their Treatments
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