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In this rat study, animals got a single injection of ibogaine at 20 mg/kg or 40 mg/kg and the researchers measured three neurotrophic factors (GDNF, BDNF, NGF) in four brain regions (VTA, prefrontal cortex, nucleus accumbens, substantia nigra) at 3 and 24 hours. The main changes appeared at 24 hours:…
In a prospective, open-label study of 30 male Special Operations veterans with mostly mild traumatic brain injury, a treatment protocol combining magnesium and oral ibogaine (MISTIC), given with other supportive care, was associated with large, statistically significant improvements in functioning and in clinician-rated PTSD, depression and anxiety scores immediately after…
In 14 people with opioid use disorder who each received a single 10 mg/kg dose of ibogaine, researchers measured blood levels of ibogaine and its metabolites over 24 hours and linked those levels to side effects. They found large differences between people in how fast ibogaine was cleared, and that…
