Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
4 papers
Researchers used PET brain scans to compare dopamine reward-system markers in 45 adults with ADHD and 41 adults without ADHD. People with ADHD scored lower on an Achievement scale (a stand-in measure for motivation), and in the ADHD group those lower scores were linked to lower availability of dopamine D2/D3…
The researchers used PET scans with [11C]UCB-J to measure SV2A, a protein that marks presynaptic nerve terminals, and tested whether a single ketamine dose changes synaptic density in the living brain. Overall, they did not find a measurable change in SV2A 24 hours after one ketamine dose in non-human primates,…
Long-term MRI studies show that people with bipolar disorder often have unusual brain changes over time, but the pattern is mixed and not fully clear. Some studies link manic episodes to faster thinning and volume loss in parts of the prefrontal cortex. A large multi-site study (307 patients, 925 controls,…
This systematic review and meta-analysis combined 311 clinical studies (653,558 children and 43,311 adults) up to August 1, 2023. It found that ADHD/hyperkinetic disorder occurred in 32.4% (95% CI 31–34%) of pediatric patients and 21.4% (95% CI 20–23%) of adult patients seen in clinical settings — about 8–9 times higher…
