Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

2 papers

Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway

Nora D. Volkow, Gou‐Jen Wang, Jeffrey H. Newcorn, Scott H. Kollins, Timothy Wigal, Frank Telang, et al.
Molecular Psychiatry Summary & key facts 2010 409 citations

Researchers used PET brain scans to compare dopamine reward-system markers in 45 adults with ADHD and 41 adults without ADHD. People with ADHD scored lower on an Achievement scale (a stand-in measure for motivation), and in the ADHD group those lower scores were linked to lower availability of dopamine D2/D3…

Attention Deficit Hyperactivity Disorder Cognitive Abilities and Testing Neural and Behavioral Psychology Studies

Prevalence of attention deficit hyperactivity disorder/hyperkinetic disorder of pediatric and adult populations in clinical settings: a systematic review, meta-analysis and meta-regression

S.C. Johnson, Eric Lim, Peter Jacoby, Stephen V. Faraone, Benjamin Minche Su, Marco Solmi, et al.
Molecular Psychiatry Summary & key facts 2025 2 citations

This systematic review and meta-analysis combined 311 clinical studies (653,558 children and 43,311 adults) up to August 1, 2023. It found that ADHD/hyperkinetic disorder occurred in 32.4% (95% CI 31–34%) of pediatric patients and 21.4% (95% CI 20–23%) of adult patients seen in clinical settings — about 8–9 times higher…

Attention Deficit Hyperactivity Disorder Bipolar Disorder and Treatment
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