Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

5 papers

Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects

Ethan B. Russo
British Journal of Pharmacology Summary & key facts 2011 1,481 citations

Some research suggests that whole-plant cannabis compounds (like THC, CBD, other cannabinoids, terpenes, and flavonoids) can interact so the plant’s effects differ from CBD alone. Healthline explains three CBD types — full-spectrum, broad-spectrum, and isolate — and notes legal, safety, and labeling limits. The article says there is evidence for…

Biochemical Analysis and Sensing Techniques Cannabis and Cannabinoid Research GABA and Rice Research

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

Attila Oláh, Balázs István Tóth, István Borbíró, Koji Sugawara, Attila Gábor Szöllősi, Gabriella Czifra, et al.

This laboratory study found that cannabidiol (CBD), a non‑psychoactive compound from Cannabis sativa, reduced fat production and inflammation in human sebaceous (oil) gland cells. The effects were seen in cultured human sebocytes and in human skin organ cultures, where CBD blocked the fat‑making (lipogenic) actions of several compounds. These results…

Biochemical Analysis and Sensing Techniques Cannabis and Cannabinoid Research Ion Channels and Receptors

Preliminary Experiments on the Chemistry and Pharmacology of Cannabis

E. W. Gill, W. D. M. Paton, Roger G. Pertwee
Nature Summary & key facts 1970 210 citations

This is a short 1970 Nature paper by E. W. Gill, W. D. Paton and R. G. Pertwee that reports preliminary experiments on the chemistry and pharmacology of cannabis. The PubMed entry has no abstract, but its indexing shows the paper looked at drug effects and toxicity, and at topics…

Biochemical Analysis and Sensing Techniques Cannabis and Cannabinoid Research Neuroscience and Neuropharmacology Research

A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol

Cinzia Citti, Pasquale Linciano, Fabiana Russo, Livio Luongo, Monica Iannotta, Sabatino Maione, et al.
Scientific Reports Summary & key facts 2019 200 citations

Researchers isolated a new natural cannabis compound called Δ9-tetrahydrocannabiphorol (Δ9-THCP) and its CBD counterpart (CBDP). In lab tests, Δ9-THCP bound very strongly to the human CB1 receptor (Ki = 1.2 nM) and caused THC-like effects in mice (less movement, pain relief, catalepsy, and lower body temperature). The authors say Δ9-THCP…

Biochemical Analysis and Sensing Techniques Cannabis and Cannabinoid Research GABA and Rice Research

The Potential Role of Cannabidiol in Cosmetic Dermatology: A Literature Review

Ai Kuzumi, Asako Yoshizaki‐Ogawa, Takemichi Fukasawa, Shinichi Sato, Ayumi Yoshizaki

This 2024 literature review examined lab, animal, and human studies on cannabidiol (CBD) for skin and cosmetic use. It says CBD is a non‑psychotropic cannabinoid and that lab and animal evidence suggests CBD may act as an antioxidant, reduce inflammation, help skin moisturize, fight acne, help wounds heal, and have…

Biochemical Analysis and Sensing Techniques Cannabis and Cannabinoid Research Psychedelics and Drug Studies
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.