Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
This review describes compounds in medicinal mushrooms and how they work in lab and animal studies. It lists many possible effects, such as immune changes, anti-inflammatory and anticancer actions, and names key molecules like polysaccharides (β-glucans), terpenes, and fungal proteins. Most evidence so far comes from in vitro or animal…
This paper is a 2015 review that brings together many studies about the lion’s mane mushroom (Hericium erinaceus). It describes the mushroom’s chemical makeup, nutrients, food uses, and about 70 identified bioactive compounds. The review reports many claimed health effects seen in cell, animal, and some human studies—such as anti-inflammatory…
In a small, double-blind, placebo-controlled trial of Japanese adults aged 50–80 with mild cognitive impairment, 30 people were randomly assigned to take Yamabushitake (an edible mushroom) or placebo for 16 weeks. The mushroom group took four 250 mg tablets three times a day and showed higher scores on a cognitive…
This review describes several medicinal mushrooms — including Lion's Mane, Reishi, Chaga, Cordyceps, Shiitake, and Turkey Tail — as low‑fat, low‑calorie foods that contain high levels of bioactive compounds (for example (1,3)(1,6)-β-d-glucans, triterpenes, phenolic compounds, and sterols). The review reports that these compounds have been linked in studies to anticancer,…
This review surveys the chemical and biological literature dealing with the isolation, structural elucidation and bioactivity of hericenones and erinacines from the fruiting body and mycelium of Hericium erinaceus, concentrating on work that has appeared in the literature up to December 2009.
In a small, randomized, placebo-controlled trial, 30 women ate Hericium erinaceus (HE) cookies or placebo cookies for 4 weeks. After HE intake, overall depression scores (CES-D) and scores for vague or indefinite complaints (ICI) were significantly lower than before. Two specific ICI items, written as "insentive" and "palpitatio," were lower…
In a randomized, double-blind, placebo-controlled trial, people took supplements containing the mushroom Hericium erinaceus for 12 weeks. The researchers gave three mental tests and found that only the Mini-Mental State Examination (MMSE) showed a statistically significant improvement and less decline in the group taking the mushroom. The authors say compounds…
This double-blind, randomised, placebo-controlled study tested a single (acute) dose of a standardized extract from the Lion’s Mane mushroom (fruiting body) in healthy younger adults. The study did not find a clear overall benefit for thinking skills or mood compared with placebo. The authors say any small benefits might only…
This systematic review looked at 26 studies on Lion’s Mane (Hericium erinaceus) published up to June 2024. The authors found some clinical trial evidence of small cognitive improvements (a combined MMSE increase of 1.17 from one RCT and one pilot trial), laboratory evidence of anti‑cancer activity in cell lines, and…
Lion's Mane is a mushroom found across the Northern Hemisphere. It is rich in nutrients and contains active compounds like polysaccharides and phenolic compounds. Some research suggests it may help brain health, nerve recovery, mood, digestion, heart health, blood sugar control, cancer prevention, and immunity. The article says it is…
