Menu
Start Screening

Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Tryptophan and brain disorders Neuroscience Systematic review

1 paper

The serotonin theory of depression: a systematic umbrella review of the evidence

Moncrieff, Joanna, Cooper, Ruth E., Stockmann, Tom, et al.
Nature Summary & key facts 2023 830 citations

This umbrella review looked at the best existing reviews and large studies to see if depression is linked to low serotonin or low serotonin activity. Across measures of serotonin in fluids, receptor and transporter studies, tryptophan depletion experiments, and large genetic studies, the evidence was mixed or absent. The authors…

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.