Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

10 papers

The Autism-Spectrum Quotient (AQ): Evidence from Asperger Syndrome/High-Functioning Autism, Males and Females, Scientists and Mathematicians

Simon Baron‐Cohen, Sally Wheelwright, Richard Skinner, Joanne Martin, Emma Clubley

The study introduced the Autism-Spectrum Quotient (AQ), a short self-test that gives a score from 0 to 50 to measure autistic traits in adults with normal intelligence. The researchers tested four groups (58 adults with Asperger/high-functioning autism; 174 random controls; 840 Cambridge students; and 16 math Olympiad winners) and found…

Autism Spectrum Disorder Research Child Development and Digital Technology Genetics and Neurodevelopmental Disorders

“Putting on My Best Normal”: Social Camouflaging in Adults with Autism Spectrum Conditions

Laura Hull, K. V. Petrides, Carrie Allison, Paula Smith, Simon Baron‐Cohen, Meng‐Chuan Lai, et al.

Researchers interviewed 92 adults with autism to study “camouflaging,” which means hiding or changing autistic behaviors in social situations. They used thematic analysis to make a three-stage model. People said they camouflage to fit in and make connections. Camouflaging included masking (hiding traits) and compensation (using learned social techniques). Reported…

Autism Spectrum Disorder Research Child Development and Digital Technology Obsessive-Compulsive Spectrum Disorders

The Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R): A Scale to Assist the Diagnosis of Autism Spectrum Disorder in Adults: An International Validation Study

Riva Ariella Ritvo, Edward Ritvo, Donald Guthrie, Max J. Ritvo, Demetra Hufnagel, William McMahon, et al.

Researchers tested the 80-question Ritvo Autism Asperger Diagnostic Scale-Revised (RAADS-R) in 779 adults at nine centers on three continents. The tool showed large score differences between 201 people with confirmed Autism Spectrum Disorder (ASD) and 578 comparison participants, and the authors concluded it is a useful tool to help clinicians…

Autism Spectrum Disorder Research Child Development and Digital Technology Genetics and Neurodevelopmental Disorders

Eye tracking in early autism research

Terje Falck‐Ytter, Sven Bölte, Gustaf Gredebäck

This review looked at eye-tracking studies of infants, toddlers, and young children with autism spectrum disorder (ASD) or at risk for ASD. Eye tracking is a non-invasive way to record where children look, and studies show early differences: reduced looking at people and faces and trouble shifting attention can appear…

Autism Spectrum Disorder Research Child Development and Digital Technology Genetics and Neurodevelopmental Disorders

Socially-induced brain ‘fertilization’: play promotes brain derived neurotrophic factor transcription in the amygdala and dorsolateral frontal cortex in juvenile rats

Nakia S. Gordon, Sharon Burke, Huda Akil, Stanley J. Watson, Jaak Panksepp
Neuroscience Letters Summary & key facts 2003 108 citations

Researchers studied 32-day-old juvenile rats that were allowed 30 minutes of rough-and-tumble play. Right after play, the rats showed higher levels of BDNF messenger RNA in the amygdala and dorsolateral frontal cortex, measured with in situ hybridization. The authors suggested this could mean play helps shape brain areas tied to…

Autism Spectrum Disorder Research Child Development and Digital Technology Neuroendocrine regulation and behavior

Why are savant skills and special talents associated with autism?

Francesca Happé
World Psychiatry Summary & key facts 2018 53 citations

Portrayals of autism spectrum disorder in film, television and literature often show special or "savant" skills: a young child who can crack advanced codes, an adult with astonishing memory, or a musician who can play any tune by ear after a single hearing. Are such portrayals realistic or helpful? Special…

Autism Spectrum Disorder Research Child Development and Digital Technology Genetics and Neurodevelopmental Disorders

Representation of autism in fictional media: A systematic review of media content and its impact on viewer knowledge and understanding of autism

Sandra C. Jones, Chloe S. Gordon, Simone Mizzi
Autism Summary & key facts 2023 49 citations

This review examined how autistic people are shown in fictional media (Part A) and whether watching those portrayals changes what people know or feel about autism (Part B). Seventeen articles met the review rules: 14 analysed portrayals and 3 tested viewer effects (those 3 included five experiments). Media studied spanned…

Autism Spectrum Disorder Research Child Development and Digital Technology Media Influence and Health

The diagnosis of ASD with MRI: a systematic review and meta-analysis

Sjir J. C. Schielen, Jesper Pilmeyer, Albert P. Aldenkamp, Svitlana Zinger
Translational Psychiatry Summary & key facts 2024 15 citations

This review combined 134 studies (159 experiments) that tried to tell apart people with autism spectrum disorder (ASD) from healthy controls using resting-state MRI. Across studies the pooled accuracy was moderate: about 76% sensitivity, 75.7% specificity, and an AUC of 0.823. However, the authors say there is a lot of…

Autism Spectrum Disorder Research Child Development and Digital Technology Genetics and Neurodevelopmental Disorders

Empathy and Autism: Establishing the Structure and Different Manifestations of Empathy in Autistic Individuals Using the Perth Empathy Scale

Jack D. Brett, David A. Preece, Rodrigo Becerra, Andrew Whitehouse, Murray T. Maybery

The present study highlights that the PES is suitable for assessing empathy across autistic and non-autistic individuals. This work with the PES also provides greater nuance to our understanding of empathy and autism, and based on these findings, we propose the empathy heterogeneity hypothesis of autism as a new way…

Autism Spectrum Disorder Research Child Development and Digital Technology Genetics and Neurodevelopmental Disorders
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