A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression
This randomized, double-blind trial tested whether six low-dose ketamine infusions over 12 days worked better than a single ketamine infusion for people with treatment-resistant depression. At 24 hours after the last infusion, there was no significant difference in clinician-rated depression scores between the group that received six ketamine infusions and…