Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

5 papers

Decarboxylation Study of Acidic Cannabinoids: A Novel Approach Using Ultra-High-Performance Supercritical Fluid Chromatography/Photodiode Array-Mass Spectrometry

Mei Wang, Yan-Hong Wang, Bharathi Avula, Mohamed M Radwan, Amira S Wanas, John van Antwerp, et al.
PubMed Central (PMC) Summary & key facts 2016 258 citations

The study heated Cannabis sativa extracts at 80, 95, 110, 130, and 145 °C for up to 60 minutes and measured acidic and neutral cannabinoids with an advanced UHPSFC/PDA‑MS lab method. Concentrations changed in an exponential way, which fits a first‑order (or pseudo‑first‑order) reaction model. The team calculated rate constants…

Cannabis and Cannabinoid Research Forensic Toxicology and Drug Analysis Psychedelics and Drug Studies

The Cannabis Terpenes

Sarana Rose Sommano, Chuda Chittasupho, Warintorn Ruksiriwanich, Pensak Jantrawut
Molecules Summary & key facts 2020 183 citations

This review explains that terpenes are the main parts of cannabis essential oils and give cannabis its smells. Hundreds of terpenes have been identified, and they shape how different cannabis types smell, how consumers experience them, and their market value. The authors say terpenes are made and stored in glandular…

Cannabis and Cannabinoid Research Plant Parasitism and Resistance Psychedelics and Drug Studies

Mechanisms of Action and Pharmacokinetics of Cannabis

Sirichai Chayasirisobhon
The Permanente Journal Summary & key facts 2020 125 citations

This review explains how the main cannabis chemicals, especially THC and CBD, act in the body and how the body absorbs and breaks them down. THC and CBD bind to cannabinoid receptors (CB1 and CB2) in the brain and other organs. Inhaling THC delivers it to blood and brain fast…

Cannabis and Cannabinoid Research Forensic Toxicology and Drug Analysis Psychedelics and Drug Studies

Health Claims About Cannabidiol Products: A Retrospective Analysis of U.S. Food and Drug Administration Warning Letters from 2015 to 2019

Kimberly G. Wagoner, Allison J. Lazard, E. Alfonso Romero‐Sandoval, Beth A. Reboussin

The study examined 39 FDA Warning Letters about CBD products issued from 2015 to 2019. It found most violations were online (websites and social media) and that nearly all letters (97%) cited companies marketing CBD as an unapproved drug. The letters also showed widespread claims that CBD could treat many…

Alcohol Consumption and Health Effects Cannabis and Cannabinoid Research Psychedelics and Drug Studies

An emerging trend in Novel Psychoactive Substances (NPSs): designer THC

Cristian Caprari, Elena Ferri, Maria Angela Vandelli, Cinzia Citti, Giuseppe Cannazza
PubMed Central (PMC) Summary & key facts 2024 27 citations

This review explains that many THC-like chemicals have been made from Δ9-THC over time. It describes their chemistry, how they are made, how they act in the body, lab testing methods, and reports from users. Some of these compounds occur in tiny amounts in natural cannabis, others are made in…

Cannabis and Cannabinoid Research GABA and Rice Research Psychedelics and Drug Studies
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