Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
In mouse hippocampal brain slices, the researchers found that Δ9‑tetrahydrocannabinol (Δ9‑THC) strongly activates CB1 cannabinoid receptors on GABA‑releasing axon terminals and reduces GABA release. The effect depended on how Δ9‑THC was dissolved, required CB1 receptors, and did not come from changing GABA receptors or GABA uptake. The results point to…
This study tested tetrahydrocannabinolic acid (THCA) in animal models of nausea and vomiting. In rats, THCA at 0.05 and 0.5 mg·kg−1 reduced LiCl-induced conditioned gaping, a behavior linked to nausea. In the house musk shrew (Suncus murinus), the same THCA doses reduced LiCl-induced vomiting. These effects were reversed by the…
The ancient Egyptians used willow bark as a remedy for aches and pains, even though they were unaware that salicylic acid was responsible for its anti-pyrogenic and anti-inflammatory actions.[1][1] Based on anecdotal reports and social media chatter, cannabis might yet displace salicylic acid as the
