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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Diet and metabolism studies Pharmacology Economics

1 paper

Ketamine treatment for depression: a review

Mani Yavi, Holim Lee, Ioline D. Henter, Lawrence T. Park, Carlos A. Zarate
Discover Mental Health Summary & key facts 2022 136 citations

This manuscript reviews the clinical evidence regarding single-dose intravenous (IV) administration of the novel glutamatergic modulator racemic (R,S)-ketamine (hereafter referred to as ketamine) as well as its S-enantiomer, intranasal esketamine, for the treatment of major depressive disorder (MDD). Initial studies found that a single subanesthetic-dose IV ketamine infusion rapidly (within…

Diet and metabolism studies Treatment of Major Depression Tryptophan and brain disorders
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