Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

4 papers

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans

Sophie Millar, Nicole L. Stone, Andrew Yates, Saoirse E. O’Sullivan
Frontiers in Pharmacology Summary & key facts 2018 522 citations

This review collected human studies on how cannabidiol (CBD) is absorbed, distributed, and cleared. From 792 records, 24 studies reported pharmacokinetic (PK) data. Results varied by how CBD was given and by formulation. For example, smoking produced faster and higher blood levels than oral or oromucosal routes. The authors concluded…

Alcohol Consumption and Health Effects Cannabis and Cannabinoid Research Diet, Metabolism, and Disease

Interpretation of Workplace Tests for Cannabinoids

Ken Kulig
PubMed Central (PMC) Summary & key facts 2016 37 citations

This article explains how workplace drug testing for marijuana usually looks for an inactive THC metabolite in urine. A positive urine test does not prove a person was impaired or recently using marijuana. Tests usually start with a quick screen and then use a lab confirmation. Urine is the most…

Alcohol Consumption and Health Effects Cannabis and Cannabinoid Research Forensic Toxicology and Drug Analysis

Health Claims About Cannabidiol Products: A Retrospective Analysis of U.S. Food and Drug Administration Warning Letters from 2015 to 2019

Kimberly G. Wagoner, Allison J. Lazard, E. Alfonso Romero‐Sandoval, Beth A. Reboussin

The study examined 39 FDA Warning Letters about CBD products issued from 2015 to 2019. It found most violations were online (websites and social media) and that nearly all letters (97%) cited companies marketing CBD as an unapproved drug. The letters also showed widespread claims that CBD could treat many…

Alcohol Consumption and Health Effects Cannabis and Cannabinoid Research Psychedelics and Drug Studies

Comparative Pharmacokinetics of Commercially Available Cannabidiol Isolate, Broad-Spectrum, and Full-Spectrum Products

Erin C. Berthold, Shyam H. Kamble, Raju S. Kanumuri, Michelle A. Kuntz, Alexandria S. Senetra, Yi‐Hua Chiang, et al.

This study gave the same oral dose of cannabidiol (CBD) to male and female rats using three product types: isolate, broad‑spectrum, and full‑spectrum. When CBD was given as a full‑spectrum product that included about 0.2% THC, CBD blood levels were higher than with isolate or broad‑spectrum. Lab tests showed THC…

Alcohol Consumption and Health Effects Cannabis and Cannabinoid Research Diet, Metabolism, and Disease
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