Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

2 papers

Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review

Joost J. Breeksema, Bouwe Kuin, Jeanine Kamphuis, Wim van den Brink, Eric Vermetten, Robert A. Schoevers
Journal of Psychopharmacology Summary & key facts 2022 161 citations

Researchers reviewed studies of drugs that act on serotonin (so-called serotonergic psychedelics) and MDMA. They found that harms and bad reactions are not clearly defined in these studies and are probably reported less often than they actually happen. Some intense or frightening experiences during treatment might help people heal, but…

Chemical synthesis and alkaloids Forensic Toxicology and Drug Analysis Psychedelics and Drug Studies MDMA Psilocybin

Methylenedioxymethamphetamine is a connectogen with empathogenic, entactogenic, and still further connective properties: It is time to reconcile “the great entactogen—empathogen debate”

Kurt Stocker, Matthias E. Liechti
Journal of Psychopharmacology Summary & key facts 2024 13 citations

The paper reviews how people use two different names for MDMA’s mind effects—"empathogen" (being open and connected to others) and "entactogen" (being connected to oneself). It finds evidence that MDMA produces both kinds of effects, that researchers use the two terms inconsistently, and that a single name—"connectogen"—better captures MDMA’s core…

Forensic Toxicology and Drug Analysis Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies
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