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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Nicotinic Acetylcholine Receptors Study Psychology The International Journal of Neuropsychopharmacology

1 paper

Default Mode Network Modulation by Psychedelics: A Systematic Review

James J Gattuso, Daniel Perkins, Simon Ruffell, Andrew J. Lawrence, Daniël Hoyer, Laura H. Jacobson, et al.
The International Journal of Neuropsychopharmacology Summary & key facts 2022 198 citations

This systematic review looked at how classic psychedelics (LSD, psilocybin, ayahuasca) change activity in the brain’s Default Mode Network (DMN). The studies commonly found an acute disruption of connectivity inside the DMN and more communication between other resting‑state brain networks during the drug experience. The authors note these DMN changes…

Chemical synthesis and alkaloids Nicotinic Acetylcholine Receptors Study Psychedelics and Drug Studies
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