Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
Microdosing means taking a very small, sub‑hallucinogenic amount of a psychedelic drug. Research so far is limited and mixed: some large observational studies report small-to-medium mood gains, but at least one randomized trial found no objective benefit. There is no standard definition of microdosing, potency and legality vary, and long‑term…
Researchers reviewed studies of drugs that act on serotonin (so-called serotonergic psychedelics) and MDMA. They found that harms and bad reactions are not clearly defined in these studies and are probably reported less often than they actually happen. Some intense or frightening experiences during treatment might help people heal, but…
Researchers used responses from the Global Drug Survey 2020 to look at how people try to treat themselves with LSD and psilocybin mushrooms. In this large international sample, many people reported positive results, but unwanted or difficult effects were reported more often than you see in carefully controlled medical studies.…
The authors reviewed 83 papers and guides about how therapists prepare people for substance-assisted psychotherapy — therapy that uses drugs like psilocybin, LSD, MDMA, or ketamine together with psychological support. They found clear agreement that good preparation before a drug session is important for safety and for helping people get…
This article reviews the idea of combining psychedelic drugs with group psychotherapy (PAGP). Using Yalom’s 11 therapeutic factors as a framework, the authors say PAGP may boost group connectedness, interpersonal learning, and prosocial behaviour, while also giving people chances to practise new ways of relating. They describe past and recent…
Researchers reviewed 19 placebo-controlled studies that tested low doses of LSD or psilocybin (this is called microdosing). The studies found measurable changes in brain biology, body responses, how people felt, and how they thought, compared with placebo. But the studies are few and small, often tested only tiny doses in…
