Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
This review explains how the mushroom drugs psilocybin and psilocin are broken down in the body. Psilocybin is mainly a pro-drug that enzymes convert into the active compound psilocin. Psilocin is then further changed, and the main substance found in urine is psilocin-O-glucuronide, which matters for clinical and forensic testing.…
This paper reviews the recent comeback of psychedelic research and points out that much of that work borrows from indigenous healing traditions. The authors say Indigenous people, ethnic and racial minorities, women, and other marginalized groups are often left out of research and the mainstream story about psychedelic medicine. The…
This paper reviews how people talk about and practice “psychedelic integration.” The authors say the term has many different definitions and many kinds of practices, which has created confusion. They present the first wide-ranging review and a new, synthesized definition and model of integration, plus a long list of integration…
Researchers looked back at recordings and interviews from 26 people who got ketamine infusions for treatment-resistant depression. They found that things people were exposed to in the days before treatment — especially digital media like videos — sometimes showed up inside their ketamine experiences and changed how emotional or “mystical”…
The Canadian Psychedelic Survey (CPS) surveyed 2,045 people in January 2022 about their use of psychedelic drugs in Canada. The survey found that psilocybin, MDMA, and LSD were the most used drugs. People most often used psychedelics for fun, self-exploration, general mental well-being, and personal growth. Large shares of respondents…
The authors created a fast lab method (LC-MS/MS) to measure the psychoactive chemicals psilocybin and psilocin in Psilocybe sclerotia, also called "magic truffles." The method was sensitive and reliable, and when used on the samples in this study it detected only psilocybin, at 59.3–167.8 µg per 100 mg of fresh…
This report describes informal ibogaine treatments given in a small program. In 24 sessions (18 aimed at addiction), a single ibogaine dose often stopped physical opioid withdrawal and created a window when people felt more able to choose. Some people stayed drug-free for months or years, but many relapsed and…
