Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

23 papers

Emotion-regulation strategies across psychopathology: A meta-analytic review

Amelia Aldao, Susan Nolen–Hoeksema, Susanne Schweizer
PubMed Summary & key facts 2010 6,290 citations

This meta-analysis combined 241 effect sizes from 114 studies to test how six habitual emotion-regulation strategies relate to symptoms of anxiety, depression, eating disorders, and substance-related problems. Rumination showed the strongest (large) link with symptoms. Avoidance, problem solving, and suppression showed medium-to-large links, while reappraisal and acceptance showed smaller (small-to-medium)…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Delivering Cognitive Behavior Therapy to Young Adults With Symptoms of Depression and Anxiety Using a Fully Automated Conversational Agent (Woebot): A Randomized Controlled Trial

Kathleen Kara Fitzpatrick, Alison Darcy, Molly Vierhile
JMIR Mental Health Summary & key facts 2017 2,318 citations

This small randomized trial tested a fully automated text-based conversational agent called Woebot as a way to deliver cognitive behavioral therapy to college-age young adults with symptoms of depression and anxiety. Over 2 weeks, the Woebot group (n=34) showed a statistically larger drop in depression scores (PHQ-9) than an information-only…

Digital Mental Health Interventions Impact of Technology on Adolescents Mental Health Research Topics

Effects of physical exercise on anxiety, depression, and sensitivity to stress

Peter Salmon
Clinical Psychology Review Summary & key facts 2001 1,332 citations

This 2001 review looked at studies on exercise, anxiety, depression, and stress. It found that short-term emotional effects of exercise are mixed, but many cross-sectional and longitudinal studies report that regular aerobic exercise training reduces anxiety and depression symptoms and may protect against the harmful effects of stress. The clearest…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Eating Disorders and Behaviors Mental Health Research Topics

Cognitive-behavioral therapy for anxiety disorders: an update on the empirical evidence

Antonia N. Kaczkurkin, Edna B. Foa

This article reviews a large body of research on cognitive-behavioral therapy (CBT) for anxiety disorders. It focuses on two common CBT methods — exposure therapy and cognitive therapy — and concludes that CBT generally works for many anxiety problems. The authors also say it is hard to compare active CBT…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

More treatment but no less depression: The treatment-prevalence paradox

Johan Ormel, Steven D. Hollon, Ronald C. Kessler, Pim Cuijpers, Scott M. Monroe
PubMed Summary & key facts 2022 188 citations

Treatments for depression have gotten better and far more people can get them since the 1980s. Yet the share of people in the general population with depression has not gone down. The authors call this the “treatment-prevalence paradox” and review seven possible explanations. They find little evidence that more cases…

Mental Health Research Topics Mental Health Treatment and Access Treatment of Major Depression

Depression and eating disorders: Treatment and course

David Mischoulon, Kamryn T. Eddy, Aparna Keshaviah, Diana Dinescu, Stephanie L. Ross, Andrea E. Kass, et al.
Journal of Affective Disorders Summary & key facts 2010 137 citations

This long study followed 246 treatment-seeking women with anorexia or bulimia for about 9 years. Major depression was common and often long-lasting: 70% of those who had depression recovered, but 65% of those who recovered later relapsed. Recovery chances varied by type of eating disorder, and time on antidepressants was…

Eating Disorders and Behaviors Mental Health Research Topics Treatment of Major Depression

Correlates of Quality of Life in Anxiety Disorders: Review of Recent Research

M. Taylor Wilmer, Kelley Anderson, Monique Reynolds
Current Psychiatry Reports Summary & key facts 2021 119 citations

The article explains “high-functioning anxiety” as ongoing anxiety that people hide while still doing well at work, school, or home. It says this is not an official diagnosis but can come from common anxiety disorders. The piece lists typical signs (like overpreparing, racing thoughts, insomnia, and people-pleasing), possible causes (work…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Perception of self and other in major depression.

Michael A. Gara, Robert L. Woolfolk, Bertram D. Cohen, Ruth B. Goldston, et al
Journal of Abnormal Psychology Summary & key facts 1993 116 citations

Researchers asked people with major depression and people without psychiatric disorders to write open, free descriptions of themselves and of other people. Compared with the control group, the depressed group named fewer positive traits and more negative traits for themselves and for parents and close others. A clustering analysis also…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Effectiveness of Digital Mental Health Tools to Reduce Depressive and Anxiety Symptoms in Low- and Middle-Income Countries: Systematic Review and Meta-analysis

Jiyeong Kim, Lois Maame Donkor Aryee, Heejung Bang, Steffi Prajogo, Yong Kyung Choi, Jeffrey S. Hoch, et al.
JMIR Mental Health Summary & key facts 2023 63 citations

The researchers did a large, careful search for studies of digital mental health tools (things like websites, phone apps, text messages, or online therapy) aimed at reducing depression and anxiety in low- and middle-income countries. They only kept randomized controlled trials, which are studies where people are randomly put into…

Digital Mental Health Interventions Impact of Technology on Adolescents Mental Health Research Topics

Psychotherapies for Generalized Anxiety Disorder in Adults: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

Davide Papola, Clara Miguel, Mariacristina Mazzaglia, Pamela Franco, Federico Tedeschi, Sara A Romero, et al.
PubMed Central (PMC) Summary & key facts 2023 63 citations

This review combined 65 randomized trials with 5,048 adults who had generalized anxiety disorder. The authors found that cognitive behavioral therapy (CBT) was linked with better short-term and long-term outcomes than treatment as usual. Third‑wave CBTs and relaxation therapy were linked with short-term benefits, but after removing studies judged to…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics

Clinical and subthreshold panic disorder

Alexander Bystritsky, Lauren Kerwin, Noosha Niv, Jaime L. Natoli, Natalie Abrahami, Ruth Klap, et al.
Depression and Anxiety Summary & key facts 2009 60 citations

This study reports that both full panic disorder (PD) and milder, “subthreshold” panic are linked with other mental health problems, trouble at work, and high use of health services. The authors used data from a large U.S. household survey to compare people with PD and varying levels of panic symptoms.…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Mental Health Research Topics Mental Health Treatment and Access

Difficulty concentrating in generalized anxiety disorder: An evaluation of incremental utility and relationship to worry

Lauren S. Hallion, Shari A. Steinman, Susan Kusmierski
Journal of Anxiety Disorders Summary & key facts 2017 59 citations

This study looked at 175 adults with generalized anxiety disorder (GAD). Clinician-rated problems with concentrating were linked to higher GAD, anxiety, and depression severity even after other GAD symptoms were taken into account. The data also showed that difficulty concentrating statistically explained part of the link between a person’s tendency…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.