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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Ibogaine Addiction Opioid

1 paper

Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models

Václav Havel, Andrew C. Kruegel, Benjamin Bechand, Scot McIntosh, Leia S. Stallings, Alana Hodges, et al.
Nature Communications Summary & key facts 2024 14 citations

Researchers made new versions of the psychedelic drug ibogaine, called oxa-iboga compounds, by changing part of the chemical structure. In lab tests on human heart cells these new compounds did not show the heart-rhythm risk that ibogaine can cause. In tests with male rats, a single dose or a short…

Alkaloids: synthesis and pharmacology Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Ibogaine
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