Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

1 paper

Psilocybin for Feeling disconnected from others

Based on 13 papers

Recent research suggests that people who take psilocybin in carefully run therapy sessions often report feeling more connected to others afterwards. These reports come from interviews, small clinical trials, and reviews, and they usually describe changes in how people think about themselves and their relationships. However, most studies are early-stage, often combine the drug with therapy and a special setting, and use small or selected groups of people, so we do not yet have strong proof that psilocybin reliably fixes social disconnection for everyone.

Key findings

  • Across many patient reports and qualitative studies, people often say they felt stronger connection with others after psychedelic treatment, including psilocybin sessions. 15092 15063
  • Clinical trials that used psilocybin together with psychotherapy have shown reductions in anxiety and depression and increases in meaning or well‑being, outcomes that are linked to greater social connection in some studies. 15063 15055 15098
  • In a study of guided psychedelic group sessions, older adults who reported feeling more connected with others before and after the sessions had bigger improvements in their overall well‑being. 15120
  • Scientists think psilocybin acts mainly at a brain site called the serotonin 2A receptor and can change how people see themselves and the world; those changes, plus increases in brain plasticity (the brain’s ability to form new connections), might help explain reports of greater social connectedness, but this is not proven. 15091 15086 15130
  • Non‑drug factors — like a person’s mindset, the physical and social environment, the relationship with therapists, music, and follow‑up therapy — strongly shape whether people feel more connected after a session. 15092 15086 15091
  • Different drugs may work in different ways for social feelings: MDMA tends to increase social openness without the classic hallucinations, while classic psychedelics such as psilocybin change perception more strongly; this means improvements in connection could come from different processes depending on the drug. 15086 15092
  • There are risks: drug‑induced hallucinations range from mild distortions to severe psychotic episodes, and a small number of people can have long‑lasting perceptual or mental health problems; clinical trials of psychedelic‑assisted therapy report adverse effects that are usually mild to moderate and short-lived but safety must be watched closely. 15080 15055 15063
  • The overall evidence is promising but limited: many trials are small, study groups are not always diverse, and no psychedelic medicine is yet approved for psychiatric conditions; researchers call for larger, more inclusive, and better‑controlled studies and for clearer ways to describe people’s subjective experiences. 15078 15098 15094 15130

Psychedelic-Assisted Psychotherapy: A Paradigm Shift in Psychiatric Research and Development

Eduardo Ekman Schenberg
Frontiers in Pharmacology Summary & key facts 2018 229 citations

This paper describes psychedelic-assisted psychotherapy, which means giving drugs like ketamine, MDMA, psilocybin, LSD or ibogaine together with guided therapy. The authors say this approach has shown promising safety and benefits so far, even for people who did not get better with usual treatments. They also argue that these therapies…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Ibogaine Ketamine
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.