Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

1 paper

LSD for Feeling disconnected from others

Based on 10 papers

A small but growing body of research suggests that psychedelic treatments can make people feel more connected to others. Many studies mix drugs, settings, and patient groups, so it is hard to say exactly how well LSD by itself helps if someone feels disconnected. The evidence is promising but limited. Researchers also warn about real risks, and they say that the way the drug is given and the therapy around it matters a lot (for good or ill). In short: some people report stronger social connection after psychedelic therapy, but most trials are small or early. Safety, long‑term effects, and whether LSD specifically is best for social disconnection are still uncertain and need more careful study.

Key findings

  • Many patients who took part in psychedelic treatments reported stronger feelings of connection with others afterward. 15092 15063
  • LSD is a classic psychedelic that acts mainly on serotonin receptors and often changes perception and thinking during the experience. 15091 15086
  • Clinical studies of psychedelic therapies are still limited in size and number, and no psychedelic medicine is officially approved yet for psychiatric conditions. 15078 15091
  • The way a treatment is carried out — the person’s mindset, the setting, and follow‑up therapy — strongly shapes whether people feel helped and whether they feel more connected. 15092 15086 15096
  • Drugs that are called entactogens (for example MDMA) tend to increase social openness and closeness more directly, while classic psychedelics (like LSD) can produce connection but often through different kinds of inner experiences. 15086 15092
  • Psychedelic therapies in clinical trials have shown reductions in anxiety, depression, and spiritual distress in seriously ill patients; many older trials used LSD or psilocybin and reported mostly short‑lived, mild to moderate side effects. 15055 15063
  • There are real risks: psychedelic drugs (including LSD) can cause hallucinations that range from mild to severe, and in some cases people can have long‑lasting perceptual problems or a higher risk of mental‑health issues afterward. 15080
  • In older adults, the immediate drug effects of psychedelics were weaker than in younger people, but feeling connected with others before and after a session predicted bigger improvements in well‑being. 15120
  • Researchers disagree or remain unsure about key questions: for example, whether the intense subjective drug experience is required for lasting social benefits, and how much benefit comes from the drug versus the therapy and social support around it. 15078 15086 15091

Hallucinations Induced by Psychoactive Drugs: Mechanisms, Consequences, and Therapeutic Interventions

This review explains how certain psychoactive drugs can cause hallucinations and why that matters. It says drugs such as psilocybin and LSD change brain chemicals called serotonin and dopamine, and that can make people see or hear things that are not there. Effects can be mild or very serious, sometimes…

Forensic Toxicology and Drug Analysis Hallucinations in medical conditions Psychedelics and Drug Studies LSD Other
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.