Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

5 papers

Post-Psychedelic Reductions in Experiential Avoidance Are Associated With Decreases in Depression Severity and Suicidal Ideation

Richard J. Zeifman, Anne Catherine Wagner, Ros Watts, Hannes Kettner, Lea J. Mertens, Robin Carhart‐Harris
Frontiers in Psychiatry Summary & key facts 2020 101 citations

Researchers followed two groups of people who planned to use a psychedelic. They gave questionnaires before the trip, then about two weeks and four weeks after. On average, people reported less avoidance of painful thoughts and feelings, lower depression scores, and less thinking about suicide after using a psychedelic. The…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Other

A Multi-Level Analysis of Biological, Social, and Psychological Determinants of Substance Use Disorder and Co-Occurring Mental Health Outcomes

Cecilia Ilaria Belfiore, Valeria Galofaro, Deborah Cotroneo, Alessia Lopis, Isabella Tringali, Valeria Denaro, et al.
Psychoactives Summary & key facts 2024 40 citations

Researchers looked at sixty studies to see how biology, social life, and psychology mix together to affect substance use problems and mental health. They found that brain systems, genes, childhood experiences, parenting, personality, and existing mood or anxiety problems all interact. This makes addiction and related psychiatric symptoms complicated, especially…

Bipolar Disorder and Treatment Cannabis and Cannabinoid Research Child and Adolescent Psychosocial and Emotional Development Cannabis Other

Examining the Potential Synergistic Effects Between Mindfulness Training and Psychedelic-Assisted Therapy

Maria Eleni Eleftheriou, Emily M Thomas
Frontiers in Psychiatry Summary & key facts 2021 37 citations

Researchers looked at studies on mindfulness training and psychedelic-assisted therapy. They found both can reduce mental-health symptoms and boost well-being. Early results also show that psychedelics can make people more mindful. Combining the two might give stronger benefits, but the evidence is still early. Bigger and better studies are needed…

Chemical synthesis and alkaloids Complementary and Alternative Medicine Studies Psychedelics and Drug Studies Other

Indigenous-Amazonian Traditional Medicine’s Usage of the Tobacco Plant: A Transdisciplinary Ethnopsychological Mixed-Methods Case Study

Ilana Berlowitz, Ernesto García Torres, Caroline Maake, Ursula Wolf, Chantal Martin‐Soelch
Plants Summary & key facts 2023 13 citations

Researchers reported a single case where a traditional Amazonian healer gave a weeklong, ritual treatment that included drinking a liquid made from the native tobacco plant. The patient was a 37-year-old woman with diagnosed low mood, anxiety, and attention problems plus a long-term physical health issue. The team used both…

Complementary and Alternative Medicine Studies Medicinal Plant Extracts Effects Psychedelics and Drug Studies Other

The potential of 5‐methoxy‐N,N‐dimethyltryptamine in the treatment of alcohol use disorder: A first look at therapeutic mechanisms of action

Stephan Tap
Addiction Biology Summary & key facts 2024 11 citations

This paper is a first look at whether the fast-acting psychedelic 5‑MeO‑DMT might help people with alcohol use disorder. The authors reviewed existing studies in humans and animals and found early signs that 5‑MeO‑DMT can cause intense mystical feelings and a loss of self-boundaries, and that it changes brain rhythms…

Cannabis and Cannabinoid Research Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies LSD Other
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