Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting in Suncus murinus
This study tested tetrahydrocannabinolic acid (THCA) in animal models of nausea and vomiting. In rats, THCA at 0.05 and 0.5 mg·kg−1 reduced LiCl-induced conditioned gaping, a behavior linked to nausea. In the house musk shrew (Suncus murinus), the same THCA doses reduced LiCl-induced vomiting. These effects were reversed by the…