Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

7 papers

Decarboxylation Study of Acidic Cannabinoids: A Novel Approach Using Ultra-High-Performance Supercritical Fluid Chromatography/Photodiode Array-Mass Spectrometry

Mei Wang, Yan-Hong Wang, Bharathi Avula, Mohamed M Radwan, Amira S Wanas, John van Antwerp, et al.
PubMed Central (PMC) Summary & key facts 2016 258 citations

The study heated Cannabis sativa extracts at 80, 95, 110, 130, and 145 °C for up to 60 minutes and measured acidic and neutral cannabinoids with an advanced UHPSFC/PDA‑MS lab method. Concentrations changed in an exponential way, which fits a first‑order (or pseudo‑first‑order) reaction model. The team calculated rate constants…

Cannabis and Cannabinoid Research Forensic Toxicology and Drug Analysis Psychedelics and Drug Studies

Use of Cannabidiol for the Treatment of Anxiety: A Short Synthesis of Pre-Clinical and Clinical Evidence

Madison Wright, Patricia Di Ciano, Bruna Brands

This review looked at animal and human studies of cannabidiol (CBD) for anxiety. In animals, CBD often reduced anxiety-like behaviors at low or medium doses but sometimes increased anxiety at high doses. Small human studies and public-speaking tests suggest CBD might reduce anxiety in healthy people and in social anxiety…

Cannabis and Cannabinoid Research Neurotransmitter Receptor Influence on Behavior

Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two

John M McPartland, Christa MacDonald, Michelle Young, Phillip S Grant, Daniel P Furkert, Michelle Glass
PubMed Central (PMC) Summary & key facts 2017 69 citations

This lab study tested how the cannabis compound THCA-A binds to the two main cannabinoid receptors (CB1 and CB2). The THCA-A sample was found to contain 2% THC, and THCA-A showed only very weak binding and little or no effect at these receptors. The authors say some of the small…

Cannabis and Cannabinoid Research GABA and Rice Research Neurotransmitter Receptor Influence on Behavior

Health Claims About Cannabidiol Products: A Retrospective Analysis of U.S. Food and Drug Administration Warning Letters from 2015 to 2019

Kimberly G. Wagoner, Allison J. Lazard, E. Alfonso Romero‐Sandoval, Beth A. Reboussin

The study examined 39 FDA Warning Letters about CBD products issued from 2015 to 2019. It found most violations were online (websites and social media) and that nearly all letters (97%) cited companies marketing CBD as an unapproved drug. The letters also showed widespread claims that CBD could treat many…

Alcohol Consumption and Health Effects Cannabis and Cannabinoid Research Psychedelics and Drug Studies

Are Sweet Dreams Made of These? Understanding the Relationship Between Sleep and Cannabis Use

Dalton Edwards, Francesca M. Filbey

This is the Modern Slavery and Human Trafficking Statement for The Scott Trust, Guardian Media Group (GMG) and The Scott Trust Endowment Limited (STEL) for the year ended 31 March 2025. It sets out policies, checks, and actions the organisations use to try to prevent modern slavery in their operations,…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research

Use of Cannabidiol in the Management of Insomnia: A Systematic Review

Rylea Ranum, Mary O. Whipple, Ivana T. Croghan, Brent Bauer, Loren Toussaint, Ann Vincent

This review looked at 34 studies that tested cannabidiol (CBD) for sleep problems. Some studies used mostly CBD and others used CBD with similar amounts of THC. Many studies reported that at least some participants had better sleep, but very few studies focused only on people with insomnia and most…

Cannabis and Cannabinoid Research Sleep and related disorders Sleep and Wakefulness Research

A Two-Phase, Dose-Ranging, Placebo-Controlled Study of the Safety and Preliminary Test of Acute Effects of Oral Δ 8 -Tetrahydrocannabivarin in Healthy Participants

Erica N. Peters, Laura MacNair, Amy Harrison, Matthew T. Feldner, Graham M.L. Eglit, Shanna Babalonis, et al.

This small two-phase trial tested single oral doses of the Δ8 form of THCV (placebo and 12.5, 25, 50, 100, 200 mg) in healthy adults and followed participants for up to 8 hours. Most side effects were mild, some doses showed a possible short-term improvement in a sustained-attention test, and…

Cannabis and Cannabinoid Research Suicide and Self-Harm Studies
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