A Review of the Mechanism of Antagonism of N-methyl-D-aspartate Receptor by Ketamine in Treatment-resistant Depression
This review explains how ketamine, a drug that blocks NMDA receptors, might work for people with treatment‑resistant depression. It says one injection of ketamine can rapidly reduce depressive symptoms, including acute suicidal behavior. The paper describes steps that could explain this: ketamine may raise glutamate, trigger growth of neuron branches,…