Frontier mental health research: psychedelics & drug studies

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2 papers

A Review of the Mechanism of Antagonism of N-methyl-D-aspartate Receptor by Ketamine in Treatment-resistant Depression

Yasar Sattar, John Wilson, Ali M Khan, Mahwish Adnan, Daniel Azzopardi Larios, Shristi Shrestha, et al.
PubMed Central (PMC) Summary & key facts 2018 49 citations

This review explains how ketamine, a drug that blocks NMDA receptors, might work for people with treatment‑resistant depression. It says one injection of ketamine can rapidly reduce depressive symptoms, including acute suicidal behavior. The paper describes steps that could explain this: ketamine may raise glutamate, trigger growth of neuron branches,…

Neurotransmitter Receptor Influence on Behavior Treatment of Major Depression Tryptophan and brain disorders

Does Bupropion Impact More than Mood? A Case Report and Review of the Literature

Waqas Yasin, Syed Ijlal Ahmed, Robert V Gouthro
Cureus Summary & key facts 2019 9 citations

This article describes one patient who developed increased sexual urges after bupropion was added to his ongoing fluoxetine treatment. The urges dropped after bupropion was stopped and replaced with mirtazapine. The authors review other studies showing bupropion usually causes fewer sexual problems than SSRIs but can sometimes raise libido, and…

Neuroendocrine regulation and behavior Sexual function and dysfunction studies Treatment of Major Depression
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