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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Neuroscience and Neuropharmacology Research Economics Current Opinion in Pharmacology

1 paper

How does ketamine elicit a rapid antidepressant response?

Ege T. Kavalali, Lisa M. Monteggia
Current Opinion in Pharmacology Summary & key facts 2014 105 citations

A single low-dose intravenous infusion of ketamine can relieve core symptoms of major depression within about two hours, with effects that can last up to two weeks. Research in animals links this fast effect to ketamine blocking NMDA receptors that are active at rest, which lowers eEF2 kinase activity and…

Neuroscience and Neuropharmacology Research Treatment of Major Depression Tryptophan and brain disorders
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.