Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

2 papers

Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options

Amir Garakani, James W. Murrough, Rafael C. Freire, Robyn P. Thom, Kaitlyn Larkin, Frank D. Buono, et al.
Frontiers in Psychiatry Summary & key facts 2020 395 citations

This review summarizes drug treatments for adult anxiety disorders (panic disorder, generalized anxiety disorder, social anxiety disorder, and specific phobias). It says well-known drugs such as SSRIs and SNRIs are commonly used and approved for some anxiety disorders. The authors found that research into truly new medications is limited, many…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Pharmacological Receptor Mechanisms and Effects Tryptophan and brain disorders

An Integrative Approach to Ketamine Therapy May Enhance Multiple Dimensions of Efficacy: Improving Therapeutic Outcomes With Treatment Resistant Depression

Muscat, Sherry-Anne, Hartelius, Glenn, Crouch, Courtenay Richards, et al.
www.frontiersin.org Summary & key facts 2021 40 citations

This paper reviews research from the last two decades showing ketamine can be a safe, fast-acting, and sustained antidepressant that helps some people with treatment-resistant depression. The authors describe several possible ways ketamine works: blocking NMDA receptors (a brain receptor), boosting new synapse growth and plasticity, reducing inflammation, creating high-entropy…

Psychedelics and Drug Studies Treatment of Major Depression Tryptophan and brain disorders
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