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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Mental Health Research Topics JAMA Psychiatry

2 papers

Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression

Ella Daly, Madhukar H. Trivedi, Adam Janik, Honglan Li, Yun Zhang, Xiang Li, et al.
JAMA Psychiatry Summary & key facts 2019 726 citations

This phase 3, double-blind trial tested whether continuing esketamine nasal spray plus an oral antidepressant could delay relapse in adults with treatment-resistant depression who had already improved after an initial esketamine course. Of 297 patients who entered the randomized phase, continuing esketamine reduced relapse compared with switching to placebo nasal…

Mental Health Research Topics Treatment of Major Depression Tryptophan and brain disorders

Psychotherapies for Generalized Anxiety Disorder in Adults: A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials

Davide Papola, Clara Miguel, Mariacristina Mazzaglia, Pamela Franco, Federico Tedeschi, Sara A Romero, et al.
PubMed Central (PMC) Summary & key facts 2023 63 citations

This review combined 65 randomized trials with 5,048 adults who had generalized anxiety disorder. The authors found that cognitive behavioral therapy (CBT) was linked with better short-term and long-term outcomes than treatment as usual. Third‑wave CBTs and relaxation therapy were linked with short-term benefits, but after removing studies judged to…

Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Child and Adolescent Psychosocial and Emotional Development Mental Health Research Topics
Summaries and links are for general information and education only. They are not a substitute for reading the original publication or for professional medical, legal, or other advice. Always refer to the linked source for the full study.