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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Pain Mechanisms and Treatments Journal of Neurochemistry

1 paper

Hericerin derivatives activates a pan‐neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory

Ramón Martínez‐Mármol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong‐Min Hong, Seon Beom Kim, et al.
Journal of Neurochemistry Summary & key facts 2023 36 citations

Researchers isolated two compounds from the medicinal mushroom Hericium erinaceus—N-de phenylethyl isohericerin (NDPIH) and hericene A. In lab cultures, these compounds caused strong axon growth and more branching in hippocampal neurons even without serum. Tests showed they activate ERK1/2 signaling and do not act only through the TrkB (BDNF) receptor.…

Fungal Biology and Applications Nerve injury and regeneration Pain Mechanisms and Treatments
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