Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

2 papers

Esketamine combined with a mindfulness-based intervention for individuals with alcohol problems

E.M. Van Gent, J. Bryan, M Cleary, Tegan I Clarke, Harry D Holmwood, Rania O Nassereddine, et al.
Journal of Psychopharmacology Summary & key facts 2024 13 citations

This small, double-blind pilot trial gave 28 people with alcohol problems either a sublingual esketamine film (115.1 mg) or a vitamin C placebo while they did two weeks of daily mindfulness practice. Compared with placebo, esketamine increased people’s psychological engagement with the meditation, produced stronger mystical and dissociative experiences, and…

Mindfulness and Compassion Interventions Treatment of Major Depression Tryptophan and brain disorders

Rapid and sustained reduction of treatment-resistant PTSD symptoms after intravenous ketamine in a real-world, psychedelic paradigm

Henry A. MacConnel, Mitch Earleywine, Steven Radowitz
Journal of Psychopharmacology Summary & key facts 2024 5 citations

This retrospective study looked at 117 outpatients with high PTSD Checklist (PCL-5) scores who received at least six intravenous ketamine sessions given in a supportive, “psychedelic” style (preparation, intention-setting, eye shades, evocative music, and integration). Average PCL-5 scores fell from 52.54 (SD = 12.01) to 28.78 (SD = 16.61), a…

Psychedelics and Drug Studies Treatment of Major Depression Tryptophan and brain disorders
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