Frontier mental health research: psychedelics & drug studies

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2 papers

Ketamine for the treatment of addiction: Evidence and potential mechanisms

Ivan Ezquerra-Romano, Will Lawn, Evgeny Krupitsky, Celia J. A. Morgan
PubMed Summary & key facts 2018 152 citations

This 2018 review looked at animal and human studies of ketamine as a possible treatment for addiction. Early findings are promising: some studies found ketamine helped people stay abstinent from alcohol and heroin and reduced cocaine craving and use. However, the authors say the research is still new, many studies…

Psychedelics and Drug Studies Treatment of Major Depression Tryptophan and brain disorders

Ketamine and serotonergic psychedelics: An update on the mechanisms and biosignatures underlying rapid-acting antidepressant treatment

Jenessa N. Johnston, Bashkim Kadriu, Josh Allen, Jessica R. Gilbert, Ioline D. Henter, Carlos A. Zarate
Neuropharmacology Summary & key facts 2023 59 citations

This paper reviews what scientists know about how ketamine and classic serotonergic psychedelics (like psilocybin and LSD) can lift depression quickly. The authors compare how the drugs work in the brain, point out that ketamine has the strongest clinical evidence so far, and say psychedelics show early promise but need…

Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies Tryptophan and brain disorders Ketamine LSD
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