Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.
This paper is a careful review of research about treatment-resistant depression. The authors looked through medical studies to see how doctors define this kind of depression, what makes it hard to assess, and which treatments have been tried. They describe drug strategies like adding lithium or thyroid hormone, switching antidepressant…
This paper reviews genetic studies that link several genes to higher risk for ADHD. It says problems in the brain's reward system—especially low dopamine activity—may make people seek things that raise dopamine. The authors propose that these gene variants form a “reward deficiency syndrome” (RDS) that may include ADHD, and…
This review looks at how psilocybin mushrooms and their active ingredient psilocin might affect the brain and mental health. The authors say that brain inflammation seems to play a role in many cases of depression and anxiety. Lab and clinical studies show that psilocin can lower brain inflammation, boost the…
