Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

6 papers

Computer-based personality judgments are more accurate than those made by humans

Wu Youyou, Michał Kosiński, David Stillwell

Researchers compared how well computers and humans can judge personality. They used data from 86,220 volunteers who took a 100-item personality questionnaire and looked at people’s Facebook Likes as the computer’s input. Computer predictions based on Likes matched the questionnaire scores better (r = 0.56) than friends’ judgments did (r…

Cognitive Abilities and Testing Evolutionary Psychology and Human Behavior Personality Traits and Psychology

Appraising the brain’s energy budget

Marcus E. Raichle, Debra A. Gusnard

This 2002 PNAS review by Marcus Raichle and Debra Gusnard examines how the brain uses energy. The authors say the brain uses a large share of the body's energy and that most of that energy goes to ongoing, background neural activity. They note that short-lived, task-related increases in energy use…

Functional Brain Connectivity Studies Mitochondrial Function and Pathology Neural dynamics and brain function

Longitudinal evidence that fatherhood decreases testosterone in human males

Lee T. Gettler, Thomas W. McDade, Alan B. Feranil, Christopher W. Kuzawa

Postpartum depression can affect fathers too. Research summarized in this article says about 10% of men experience clinical paternal postpartum depression, often during pregnancy or in the first year after birth (with the highest risk in the first 3–6 months). The article lists common symptoms, risk factors like a partner’s…

Evolutionary Psychology and Human Behavior Neuroendocrine regulation and behavior Reproductive Health and Technologies

Transformative experience and social connectedness mediate the mood-enhancing effects of psychedelic use in naturalistic settings

Matthias Forstmann, Daniel Alexander Yudkin, Annayah Miranda Beatrice Prosser, S. Megan Heller, Molly J. Crockett

Researchers studied more than 1,200 people at six multiday mass gatherings in the US and the UK. They found that psychedelic use was linked with better mood. That link appeared to work through people reporting a transformative experience and feeling more socially connected. The link was stronger when use had…

Biochemical Analysis and Sensing Techniques Chemical synthesis and alkaloids Psychedelics and Drug Studies

Elevated morning cortisol is a stratified population-level biomarker for major depression in boys only with high depressive symptoms

Matthew Owens, J. Herbert, Peter B. Jones, Barbara J. Sahakian, Paul Wilkinson, Valerie Dunn, et al.

The researchers repeatedly measured early-morning cortisol and self-reported depressive symptoms in a population of adolescents. Using a statistical method to find subgroups, they identified a high-risk group (17% of the sample) with both high depressive symptoms and elevated morning cortisol. Membership in this group was linked to worse autobiographical memory…

Child and Adolescent Psychosocial and Emotional Development Stress Responses and Cortisol Tryptophan and brain disorders
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