Frontier mental health research: psychedelics & drug studies

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2 papers

Psychological flexibility as a mechanism of change in psilocybin-assisted therapy for major depression: results from an exploratory placebo-controlled trial

Sloshower, Jordan, Zeifman, Richard J., Guss, Jeffrey, et al.
Nature Summary & key facts 2024 46 citations

This small, exploratory study gave people with moderate to severe major depressive disorder placebo first (19 people) and then a single dose of psilocybin (0.3 mg/kg) to 15 people four weeks later, with all dosing embedded in therapy based on Acceptance and Commitment Therapy (ACT). After the psilocybin session, measures…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies

Improvement in OCD symptoms associated with serotoninergic psychedelics: a retrospective online survey

Anne Buot, Cecile Pallares, A. P. Oganesyan, Charles Dauré, Valérie Bonnelle, Eric Burguière, et al.
Scientific Reports Summary & key facts 2023 27 citations

Researchers ran an online survey of about 174 people who had used psychoactive drugs to see how these drugs affected obsessive–compulsive disorder (OCD) symptoms. Participants reported that classic psychedelics were the only drugs that helped reduce OCD symptoms, and bigger immediate effects (which were linked to higher doses) were tied…

Chemical synthesis and alkaloids Neurotransmitter Receptor Influence on Behavior Psychedelics and Drug Studies
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