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Frontier mental health research: psychedelics & drug studies

Each month our editorial team sifts through hundreds of papers and curates notable findings—for practitioners and informed readers who want to stay current with the evidence. Subscribe to the monthly Research Digest for expert analysis and concise summaries of key papers.

Biochemical Analysis and Sensing Techniques Medicine Scientific reports

3 papers

A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol

Cinzia Citti, Pasquale Linciano, Fabiana Russo, Livio Luongo, Monica Iannotta, Sabatino Maione, et al.
Scientific Reports Summary & key facts 2019 200 citations

Researchers isolated a new natural cannabis compound called Δ9-tetrahydrocannabiphorol (Δ9-THCP) and its CBD counterpart (CBDP). In lab tests, Δ9-THCP bound very strongly to the human CB1 receptor (Ki = 1.2 nM) and caused THC-like effects in mice (less movement, pain relief, catalepsy, and lower body temperature). The authors say Δ9-THCP…

Biochemical Analysis and Sensing Techniques Cannabis and Cannabinoid Research GABA and Rice Research

Psychedelics alter metaphysical beliefs

Christopher Timmermann, Hannes Kettner, Chris Letheby, Leor Roseman, Fernando E. Rosas, Robin Carhart‐Harris
Scientific Reports Summary & key facts 2021 195 citations

Researchers used a large prospective online survey to test whether psychedelic drug use changes people’s metaphysical beliefs. After psychedelic use, people tended to move away from physicalist or materialist views and toward panpsychism and fatalism. Except for fatalism, these shifts lasted for at least 6 months. The shifts were linked…

Biochemical Analysis and Sensing Techniques Chemical synthesis and alkaloids Psychedelics and Drug Studies

Adults who microdose psychedelics report health related motivations and lower levels of anxiety and depression compared to non-microdosers

Joseph M. Rootman, Pamela Kryskow, Kalin Harvey, Paul Stamets, Eesmyal Santos-Brault, Kim P. C. Kuypers, et al.
Scientific Reports Summary & key facts 2021 75 citations

This study used a smartphone app to compare 4,050 people who said they microdose psychedelics with 4,653 people who did not. Psilocybin was the most common microdose substance, and people who microdosed often said they did so for health and wellness reasons. In people who reported past mental health concerns,…

Biochemical Analysis and Sensing Techniques Chemical synthesis and alkaloids Psychedelics and Drug Studies
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