A Nationwide Target Trial Emulation Assessing the Risk of Antidepressant-Induced Mania Among Patients With Bipolar Depression
This study used nationwide Danish health records to compare 979 people with bipolar depression who had just been discharged from a psychiatric ward. Of these, 358 received antidepressants and 621 did not. The researchers followed everyone for 1 year and, after adjusting for baseline factors, found no statistically significant increase…